Treatment adherence with the easypod™ growth hormone electronic auto-injector and patient acceptance: survey results from 824 children and their parents
Identifieur interne : 000776 ( Main/Exploration ); précédent : 000775; suivant : 000777Treatment adherence with the easypod™ growth hormone electronic auto-injector and patient acceptance: survey results from 824 children and their parents
Auteurs : Mauro Bozzola [Italie] ; Michel Colle [France] ; Maria Halldin-Stenlid [Suède] ; Sylvain Larroque [Allemagne] ; Monia Zignani [Allemagne]Source :
- BMC Endocrine Disorders [ 1472-6823 ] ; 2011.
Abstract
Accurately monitoring adherence to treatment with recombinant human growth hormone (r-hGH) enables appropriate intervention in cases of poor adherence. The electronic r-hGH auto-injector, easypod™, automatically records the patient's adherence to treatment. This study evaluated adherence to treatment of children who started using the auto-injector and assessed opinions about the device.
A multicentre, multinational, observational 3-month survey in which children received r-hGH as part of their normal care. Physicians reviewed the recorded dose history and children (with or without parental assistance) completed a questionnaire-based survey. Children missing ≤2 injections per month (92% of injections given) were considered adherent to treatment. Adherence was compared between GH treatment-naïve and treatment-experienced children.
Of 834 recruited participants, 824 were evaluated. The median (range) age was 11 (1-18) years. From the recorded dose history, 87.5% of children were adherent to treatment over the 3-month period. Recorded adherence was higher in treatment-naïve (89.7%, n = 445/496) than in treatment-experienced children (81.7%, n = 152/186) [Fisher's exact test FI(X) = 7.577;
easypod™ provides an accurate method of monitoring adherence to treatment with r-hGH. In children who received treatment with r-hGH using easypod™, short-term adherence is good, and significantly higher in treatment-naïve children compared with experienced children. Children/parents rate the device highly. The high level of acceptability of the device is reflected by a desire to continue using it by over 90% of the children in the survey.
Url:
DOI: 10.1186/1472-6823-11-4
PubMed: 21294891
PubMed Central: 3045978
Affiliations:
- Allemagne, France, Italie, Suède
- District de Darmstadt, East Middle Sweden, Hesse (Land), Svealand
- Bordeaux, Darmstadt, Uppsala
- Université d'Uppsala
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Le document en format XML
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Geneva, Switzerland, an affiliate of Merck KGaA, Darmstadt, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Merck Serono S.A. - Geneva, Switzerland, an affiliate of Merck KGaA, Darmstadt</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Darmstadt</settlement></placeName></affiliation></author><author><name sortKey="Zignani, Monia" sort="Zignani, Monia" uniqKey="Zignani M" first="Monia" last="Zignani">Monia Zignani</name><affiliation wicri:level="3"><nlm:aff id="I4">Merck Serono S.A. - Geneva, Switzerland, an affiliate of Merck KGaA, Darmstadt, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Merck Serono S.A. - Geneva, Switzerland, an affiliate of Merck KGaA, Darmstadt</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Darmstadt</settlement></placeName></affiliation></author></analytic><series><title level="j">BMC Endocrine Disorders</title><idno type="eISSN">1472-6823</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Accurately monitoring adherence to treatment with recombinant human growth hormone (r-hGH) enables appropriate intervention in cases of poor adherence. The electronic r-hGH auto-injector, easypod™, automatically records the patient's adherence to treatment. This study evaluated adherence to treatment of children who started using the auto-injector and assessed opinions about the device.</p></sec><sec><title>Methods</title><p>A multicentre, multinational, observational 3-month survey in which children received r-hGH as part of their normal care. Physicians reviewed the recorded dose history and children (with or without parental assistance) completed a questionnaire-based survey. Children missing ≤2 injections per month (92% of injections given) were considered adherent to treatment. Adherence was compared between GH treatment-naïve and treatment-experienced children.</p></sec><sec><title>Results</title><p>Of 834 recruited participants, 824 were evaluated. The median (range) age was 11 (1-18) years. From the recorded dose history, 87.5% of children were adherent to treatment over the 3-month period. Recorded adherence was higher in treatment-naïve (89.7%, n = 445/496) than in treatment-experienced children (81.7%, n = 152/186) [Fisher's exact test FI(X) = 7.577; <italic>p </italic>= 0.0062]. According to self-reported data, 90.2% (607/673) of children were adherent over 3 months; 51.5% (421/817) missed ≥1 injection over this period (mainly due to forgetfulness). Concordance between reported and recorded adherence was 84.3%, with a trend towards self-reported adherence being higher than recorded adherence. Most children liked the auto-injector: over 80% gave the top two responses from five options for ease of use (720/779), speed (684/805) and comfort (716/804). Although 38.5% (300/780) of children reported pain on injection, over half of children (210/363) considered the pain to be less or much less than expected. Given the choice, 91.8% (732/797) of children/parents would continue using the device.</p></sec><sec><title>Conclusions</title><p>easypod™ provides an accurate method of monitoring adherence to treatment with r-hGH. In children who received treatment with r-hGH using easypod™, short-term adherence is good, and significantly higher in treatment-naïve children compared with experienced children. Children/parents rate the device highly. The high level of acceptability of the device is reflected by a desire to continue using it by over 90% of the children in the survey.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Farber, Rs" uniqKey="Farber R">RS Farber</name></author><author><name sortKey="Kerrigan, Jr" uniqKey="Kerrigan J">JR Kerrigan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laursen, T" uniqKey="Laursen T">T Laursen</name></author><author><name sortKey="Jorgensen, Jo" uniqKey="Jorgensen J">JO Jorgensen</name></author><author><name sortKey="Christiansen, Js" uniqKey="Christiansen J">JS Christiansen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mesa, J" uniqKey="Mesa J">J Mesa</name></author><author><name sortKey="Gomez, Jm" uniqKey="Gomez J">JM Gomez</name></author><author><name sortKey="Hernandez, C" uniqKey="Hernandez C">C Hernandez</name></author><author><name 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Kirk</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>France</li><li>Italie</li><li>Suède</li></country><region><li>District de Darmstadt</li><li>East Middle Sweden</li><li>Hesse (Land)</li><li>Svealand</li></region><settlement><li>Bordeaux</li><li>Darmstadt</li><li>Uppsala</li></settlement><orgName><li>Université d'Uppsala</li></orgName></list><tree><country name="Italie"><noRegion><name sortKey="Bozzola, Mauro" sort="Bozzola, Mauro" uniqKey="Bozzola M" first="Mauro" last="Bozzola">Mauro Bozzola</name></noRegion></country><country name="France"><noRegion><name sortKey="Colle, Michel" sort="Colle, Michel" uniqKey="Colle M" first="Michel" last="Colle">Michel Colle</name></noRegion></country><country name="Suède"><region name="Svealand"><name sortKey="Halldin Stenlid, Maria" sort="Halldin Stenlid, Maria" uniqKey="Halldin Stenlid M" first="Maria" last="Halldin-Stenlid">Maria Halldin-Stenlid</name></region></country><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Larroque, Sylvain" sort="Larroque, Sylvain" uniqKey="Larroque S" first="Sylvain" last="Larroque">Sylvain Larroque</name></region><name sortKey="Zignani, Monia" sort="Zignani, Monia" uniqKey="Zignani M" first="Monia" last="Zignani">Monia Zignani</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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